Search results for "Intracellular release"

showing 2 items of 2 documents

Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles

2014

Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ramón Martínez-Máñez,1–3 José Ramón Murguía1,3 1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain; 2Departamento de Química, Universidad Politécnica de Valencia, Valenci…

INGENIERIA DE LA CONSTRUCCIONMaterials scienceAntifungal AgentsPH-responsive nanoparticlesCell Survivalmedia_common.quotation_subjectCapped mesoporous nanoparticlesBiophysicsPharmaceutical ScienceNanoparticleBioengineeringSaccharomyces cerevisiaeNanocapsulesBiomaterialsDiffusionchemistry.chemical_compoundNanoporesQUIMICA ORGANICANanocapsulesInternational Journal of NanomedicineDrug DiscoveryQUIMICA ANALITICABIOQUIMICA Y BIOLOGIA MOLECULARFluoresceinParticle SizeCytotoxicityInternalizationmedia_commonTebuconazoleOriginal ResearchIntracellular releaseOrganic ChemistryQUIMICA INORGANICADrug SynergismGeneral MedicineMesoporous silicaHydrogen-Ion ConcentrationTriazoleschemistryBiochemistryDelayed-Action PreparationsBiophysicsTebuconazole loadingMesoporous materialPorosityInternational Journal of Nanomedicine
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Enzyme-responsive intracellular-controlled release using silica mesoporous nanoparticles capped with ε-poly-L-lysine.

2014

The synthesis and characterization of two new capped silica mesoporous nanoparticles for controlled delivery purposes are described. Capped hybrid systems consist of MCM-41 nanoparticles functionalized on the outer surface with polymer epsilon-poly-L-lysine by two different anchoring strategies. In both cases, nanoparticles were loaded with model dye molecule [Ru(bipy)(3)](2+). An anchoring strategy involved the random formation of urea bonds by the treatment of propyl isocyanate-functionalized MCM-41 nanoparticles with the lysine amino groups located on the epsilon-poly-L-lysine backbone (solid Ru-rLys-S1). The second strategy involved a specific attachment through the carboxyl terminus of…

Silicon dioxideNanoparticlemesoporous materialsCatalysisRutheniumchemistry.chemical_compoundHydrolysisQUIMICA ORGANICACell Line TumorQUIMICA ANALITICAOrganic chemistryHumansPolylysineColoring Agentschemistry.chemical_classificationintracellular releaseOrganic ChemistryQUIMICA INORGANICAGeneral ChemistryPolymerMesoporous silicaSilicon DioxideControlled releaseCombinatorial chemistrychemistryPolylysineDelayed-Action Preparationsanchoring strategyNanoparticlesnanoparticlesMesoporous materialLysosomesPorositypoly-L-lysineHeLa CellsChemistry (Weinheim an der Bergstrasse, Germany)
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